Personalised cancer treatment – known markers and what they mean for treatment
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Known markers and what they mean for treatment
Overview
Drug target markers
Diagnostic and prognostic markers
Meta description
Keywords
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Known markers and what they mean for treatment
Overview
Personalised, targeted and hormonal treatments all depend on genetic mutations that can be identified in cancer cells to be effective. These mutations are sometimes referred to as “markers”. The markers can manifest through over-expression, lack of expression or mutated expression of specific proteins.
Some markers can be targeted using specific treatments whereas some can act as measurements for disease diagnosis, prognosis and treatment response.
Drug target markers
The genes listed below have all been associated in cancer, the majority of which can also be treated.
Known marker
Cancers they’re associated with / may benefit from targeted therapy
Related treatment/response to treatment
ALK[EB1] – anaplastic lymphoma kinase (*)
Anaplastic large-cell lymphoma
Familial neuroblastoma (nerve cell)
Non-small cell lung cancer (NSCLC)
Crizotinib (Xalkori®)
Pemetrexed (Alimta®)
AR – androgen receptor
Bladder
Breast
NSCLC
Ovarian
Prostate
Abarelix (Plenaxis®)
Bicalutamide (Casodex®)
Flutamide (Eulexin®)
Gonadorelin (Factrel®)
Goserelin (Zoladex®)
Leuprolide (Lupron®)
BRAF – v-raf murine sarcoma viral oncogene homolog B1
Colon
Lung
Melanoma (skin)
Nervous system
Thyroid
Cetuximab (Erbitux®)
Panitumumab (Vectibix®)
Vemurafenib (Zelboraf®)
BRCA1 – breast cancer susceptibility gene 1
Breast
Lung
Ovarian
Cisplatin (Platinol®)
Prophylactic surgery (prevention)
BRCA2 – breast cancer susceptibility gene 2
Breast
Ovarian
Tamoxifen (Nolvadex®)
Prophylactic surgery (prevention)
c-Kit/CD117/SCFR – mast stem cell factor receptor (*)
Acute myelogenous leukemia (AML)
Gastrointestinal stromal tumour (GIST)
Melanoma
Imatinib (Gleevec®)
Sorafenib (Nexavar®)
Sunitinib (Sutent®)
c-MET/HGFR – mesenchymal epithelial transition factor/hepatocyte growth factor receptor
NSCLC
Ovarian
Erlotinib (Tarceva®)
Gefitinib (Iressa®)
COX-2/PTGS2 – cyclooxygenase-2/ prostaglandin-endoperoxide synthase-2
NSCLC
Celecoxib (Celebrex®)
EGFR/ErbB-1/HER1 – epidermal growth factor receptor (*)
NSCLC
Cetuximab (Erbitux®)
Erlotinib (Tarceva®)
Gefitinib (Iressa®)
Panitumumab (Vectibix®)
ER – oestrogen receptor (*)
Breast
Female reproductive tract (cervical, fallopian, ovarian, uterine)
Anastrazole (Arimidex®)
Exemestane (Aromasin®)
Fulvestrant (Faslodex®)
Goserelin (Zoladex®)
Letrozole (Femara®)
Leuprolide (Eligard®, Lupron®, Viadur®)
Medroxyprogesterone, (Provera®, Amen®, Curretab®, Cycrin®)
Megestrol acetate (Megace®, Megace® ES)
Tamoxifen (Nolvadex®)
Toremifene (Fareston®)
ERCC1 – excision repair cross-complementation group 1
Bladder
Colorectal
Gastric
Lung (NSCLC and SCLC)
Ovarian
Carboplatin (Paraplatin®)
Oxaliplatin (Eloxatin®)
HER2/HER2neu/ErbB-2 – human epidermal growth factor receptor 2 (*)
Breast
Colorectal
Gastric
Gastroesophageal
Ovarian
Doxorubicin (Adriamycin®, Rubex®)
Epirubicin (Ellence®)
Lapatinib (Tykerb®)
Liposomal doxorubicin (Caelyx®, Myocet®),
Trastuzumab (Herceptin®)
KRAS – Kirsten murine sarcoma virus (*)
Colon
NSCLC
Pancreatic
Cetuximab (Erbitux®)
Erlotinib (Tarceva®)
Gefitinib (Iressa®)
Panitumumab (Vectibix®)
MGMT – O-6-methylguanine-DNA methyltransferase
Breast
Glioblastoma multiforme (brain)
Melanoma
NSCLC
Oesophageal
Oligodendrogliomas
Pituitary gland carcinoma
Resistant to temozolomide (Temodar®)
MRP1 – multidrug resistance-associated protein 1
Breast
Head and neck
Lymphoma
Resistant to doxorubicin (Adrimycin®), vinca alkaloids, methotrexate (Trexall®)
PGP – p-glycoprotein
Breast
Head and neck
Lymphoma
Ovarian
Resistant to doxorubicin (Adriamycin®), epirubicin (Ellence®), liposomal-doxorubicin (Doxil®), paclitaxel (Taxol®), docetaxel (Taxotere®), vinblastine (Velban®), vincristine (Oncovin®), vinorelbine (Navelbine®)
PIK3CA? – phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Breast
Colorectal
Gastric
Glioblastoma
Lung
Ovarian
Lapatinib (Tykerb®)
Resistant to cetuximab (Erbitux®), panitumumab (Vectibix)
Decreased response to trastuzumab (Herceptin®)
PR – progesterone receptor (*)
Breast
Female genital tract cancer
Ovarian
Anastrozole (Arimidex®)
Exemestane (Aromasin®)
Foremifene (Fareston®)
Fulvestrant (Faslodex®)
Gonadorelin (Factrel®)
Goserelin (Zoladex®)
Letrozole (Femara®)
Leuprolide (Eligard®, Lupron®, Viadur®)
Medroxyprogesterone (Provera®, Amen®, Curretab®, Cycrin®)
Megestrol acetate (Megace®, Megace® ES)
Tamoxifen (Nolvadex®)
PTEN – phosphatase and tensin homolog
Breast
Colon
Glioblastoma
Head and neck
NSCLC
Resistant to cetuximab (Erbitux®), erlotinib (Tarceva®), gefitinib (Iressa®), panitumumab (Vectibix®), trastuzumab (Herceptin®)
RRM1– ribonucleotide reductase subunit M1
NSCLC
Pancreatic
Decreased response to gemcitabine (Gemzar®), hydroxyurea (Hydrea®, Droxia®)
SPARC – secreted protein acidic rich in cysteine
Breast
Gastric
Head and neck
Melanoma
Pancreatic
Albumin-bound paclitaxel/nab-paclitaxel (Abraxane®)
TLE3 – transducin-like enhancer of split
Breast
Ovarian
Docetaxel (Taxotere ®)
Paclitaxel (Taxol®),
TOPO2? – topoisomerase II?
Breast
Colon
SCLC
Ovarian
Doxorubicin (Adriamycin®)
Epirubicin (Ellence®, Pharmorubucin®)
Liposomal doxorubicin (Caelyx®, Myocet®)
TS – thymidylate synthetase
Breast
Colon
Gastric
Head and neck
Liver
NSCLC
Pancreatic
Resistant to 5-fluorouracil (Adrucil®), cytarabine (Cytosar-U®), pemetrexed (Alimta®)
TUBB3 – Class III -tubulin
NSCLC
Ovarian
Docetaxel (Taxotere ®)
Paclitaxel (Taxol®)
Vinorelbine (Navelbine®)
(*) – Targetable genes and proteins that can also be measured to determine treatment response, cancer diagnosis and prognosis.
Diagnostic and prognostic markers
The following markers are all related to diagnosis, prognosis and treatment progress.
Known marker
Associated cancer
Role
? (alpha)-fetoprotein
Germ cell
Liver
Germ cell tumour staging, prognosis, response to treatment
Liver cancer diagnosis, response to treatment
? (beta)-2-microglobulin
Chronic lymphocytic leukaemia (CLL)
Lymphoma
Multiple myeloma
Prognosis, response to treatment
? (beta)-human chorionic gonadotropin (?-hCG)
Choriocarcinoma (uterine)
Testicular
Staging, prognosis, response to treatment
BCR-ABL fusion gene
Chronic myeloid leukaemia (CML)
Diagnosis, disease status monitoring
BRAF (mutation V600E)
Colorectal
Melanoma
Response to targeted treatment
CA15-3/CA27.29
Breast
Treatment success, disease recurrence
CA19-9
Bile duct
Gallbladder
Gastric
Pancreatic
Treatment success
CA-125
Ovarian
Diagnosis, treatment response, disease recurrence
Calcitonin
Medullary thyroid
Diagnosis, treatment success, disease recurrence
Carcinoembryonic antigen (CEA)
Breast
Colorectal
Breast cancer recurrence, treatment response
Colorectal disease advance
CD20
Non-Hodgkin lymphoma (NHL)
Response to targeted treatment
Chromogranin A (CgA)
Neuroendocrine tumours
Diagnosis, treatment response, disease recurrence
Chromosomes 3, 7, 17, 9p21
Bladder
Disease recurrence
Cytokeratin fragments 21-1
Lung
Disease recurrence
Fibrin/fibrinogen
Bladder
Treatment response
Human epididymis protein 4 (HE4)
Ovarian
Disease progression, disease recurrence
Immunoglobulins (antibodies)
Multiple myeloma (MM)
Waldenstrom macroglobulinemia (blood)
Diagnosis, treatment response, disease recurrence
Lactate dehydrogenase
Germ cell tumours
Staging, prognosis, treatment response
Nuclear matrix protein 22
Bladder
Treatment response
Plasminogen activator inhibitor (PAI-1)
Breast
Grading, treatment planning
Prostate-specific antigen (PSA)
Prostate
Diagnosis, treatment response, disease recurrence
Thyroglobulin
Thyroid
Treatment response, disease recurrence
Urokinase plasminogen activator (uPA)
Breast
Grading, treatment planning
Meta description
Cancer markers can help with the diagnosis and treatment of cancer and can give access to targeted therapies.
Keywords
Cancer markers, genetic markers, diagnostic markers, drug target markers
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Checked Sep 2014
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